Anticancer effect of CKD-602(belotecan, camtobell(R)) on the oral cancer cell lines
Journal of the Korean Association of Oral and Maxillofacial Surgeons
;
: 7-12, 2005.
Artículo
en Coreano
| WPRIM
| ID: wpr-205203
ABSTRACT
PURPOSE:
CKD-602, a newly developed water-soluble campthotecin analogue, is a anticancer agent which act as a DNA topoisomerase I inhibitor. CKD-602 is known as more potent and tolerable agent. The main purposes of this study were to measure the cytotoxic effect of CKD-602 on the oral cancer cell lines and to evaluate the apoptotic aspect of dead cells. MATERIALS ANDMETHODS:
To determine the cytotoxic effect of CKD-602 on the oral cancer cell lines in comparison with various cell lines, such as lung cancer and colon cancer cell lines, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide(MTT) assay was performed. And apoptosis was analyzed using fluorescence-activated cell sorting(FACS) system.RESULTS:
CKD-602 decreased the viability of malignant cells in a dose dependent manner and in a time dependent manner. CKD-602 showed excellent cytotoxicity to the oral cancer cell lines. Also, apoptotic portion was increased in a dose dependent manner.CONCLUSION:
These findings indicated that CKD-602 induced apoptotic cell death in the various cell lines including oral cancer cell lines. From the results, it was suggested that CKD-602 would be a potential therapeutic agent for the oral cancer. More successive researches on the anticancer effect of CKD-602 should be performed.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Camptotecina
/
Neoplasias de la Boca
/
Línea Celular
/
Muerte Celular
/
Apoptosis
/
Neoplasias del Colon
/
ADN-Topoisomerasas de Tipo I
/
Neoplasias Pulmonares
Idioma:
Coreano
Revista:
Journal of the Korean Association of Oral and Maxillofacial Surgeons
Año:
2005
Tipo del documento:
Artículo
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