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Prognostic Significance of Preoperative C-Reactive Protein Elevation and Thrombocytosis in Patients with Non-Metastatic Renal Cell Carcinoma
Korean Journal of Urology ; : 104-109, 2011.
Artículo en Inglés | WPRIM | ID: wpr-205234
ABSTRACT

PURPOSE:

The aim of this study was to investigate the association of preoperative C-reactive protein (CRP) elevation and thrombocytosis with the prognosis of patients with non-metastatic renal cell carcinoma (RCC). MATERIALS AND

METHODS:

This was a retrospective review of the medical records of 177 patients (130 men and 47 women) with non-metastatic RCC who underwent a radical nephrectomy between March 2000 and May 2008 and for whom preoperative CRP and platelet data were available for analysis. Preoperative CRP elevation and thrombocytosis were compared with clinical and pathological variables.

RESULTS:

There were 38 patients with CRP elevation and 11 patients with thrombocytosis. The mean follow-up time was 48.3 months (median, 48.0; range, 13-111 months). Twenty-three patients (13.0%) developed metastases and six patients died during the follow-up period. CRP elevation was significantly correlated with anemia (p=0.001), T stage (p=0.004), grade (p=0.025), and metastasis (p<0.001). Thrombocytosis was significantly correlated with anemia (p=0.003), T stage (p=0.002), and metastasis (p=0.001). The univariate analysis identified anemia, CRP elevation, thrombocytosis, tumor histology subtype, tumor size, T stage, and grade as significant prognostic factors associated with recurrence-free survival, whereas the multivariate analyses showed that CRP elevation (p=0.033) and tumor size (p=0.007) were independent prognostic factors.

CONCLUSIONS:

Preoperative CRP elevation and thrombocytosis were associated with a poorer prognosis and a higher recurrence rate in patients with non-metastatic RCC. Moreover, preoperative CRP elevation appeared to be an independent predictor of tumor recurrence and prognosis. Preoperative thrombocytosis, however, was not an independent prognostic factor for tumor recurrence and prognosis.
Asunto(s)

Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Pronóstico / Recurrencia / Trombocitosis / Plaquetas / Proteína C-Reactiva / Carcinoma de Células Renales / Registros Médicos / Análisis Multivariante / Estudios Retrospectivos / Estudios de Seguimiento Tipo de estudio: Estudio observacional / Estudio pronóstico / Factores de riesgo Límite: Humanos / Masculino Idioma: Inglés Revista: Korean Journal of Urology Año: 2011 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Pronóstico / Recurrencia / Trombocitosis / Plaquetas / Proteína C-Reactiva / Carcinoma de Células Renales / Registros Médicos / Análisis Multivariante / Estudios Retrospectivos / Estudios de Seguimiento Tipo de estudio: Estudio observacional / Estudio pronóstico / Factores de riesgo Límite: Humanos / Masculino Idioma: Inglés Revista: Korean Journal of Urology Año: 2011 Tipo del documento: Artículo