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ADAM33 Polymorphisms Are Associated with Susceptibility to Systemic Lupus Erythematosus in a Korean Population
Journal of Rheumatic Diseases ; : 88-95, 2016.
Artículo en Inglés | WPRIM | ID: wpr-205477
ABSTRACT

OBJECTIVE:

The objective of this study is to assess whether genetic functional variants of disintegrin and metalloprotease 33 (ADAM33) are associated with susceptibility to systemic lupus erythematosus (SLE) in a Korean population.

METHODS:

We previously identified 48 single nucleotide polymorphisms (SNPs) in ADAM33. Six SNPs were selected with regard to the linkage disequilibrium pattern. An association study of ADAM33 was conducted in 190 patients with SLE and 469 control subjects. SNPs were genotyped using the TaqMan Real-time polymerase chain reaction method, and haplotype analyses of related variants were performed.

RESULTS:

All SNPs were in Hardy-Weinberg equilibrium. Significant associations were found between the ADAM33 polymorphisms and SLE at rs2787094 (adjusted odds ratio [OR] 1.88, 95% confidence interval [CI] 1.00 to 3.54; p<0.0001). The rs554743 polymorphism was associated with the presence of the immunoglobulin M anti-cardiolipin antibody (adjusted OR 0.29, 95% CI 0.10 to 0.83; p=0.021).

CONCLUSION:

ADAM33 polymorphisms were associated with susceptibility to SLE and development of clinical disease manifestations in a Korean population. Further study is warranted to clarify the role of ADAM33 in SLE pathogenesis.
Asunto(s)

Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Haplotipos / Inmunoglobulina M / Desequilibrio de Ligamiento / Oportunidad Relativa / Polimorfismo de Nucleótido Simple / Reacción en Cadena en Tiempo Real de la Polimerasa / Lupus Eritematoso Sistémico Tipo de estudio: Estudio de etiología Límite: Humanos Idioma: Inglés Revista: Journal of Rheumatic Diseases Año: 2016 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Haplotipos / Inmunoglobulina M / Desequilibrio de Ligamiento / Oportunidad Relativa / Polimorfismo de Nucleótido Simple / Reacción en Cadena en Tiempo Real de la Polimerasa / Lupus Eritematoso Sistémico Tipo de estudio: Estudio de etiología Límite: Humanos Idioma: Inglés Revista: Journal of Rheumatic Diseases Año: 2016 Tipo del documento: Artículo