Extrapancreatic Effect of Glucagon like Peptide-1 / 대한내과학회지
Korean Journal of Medicine
;
: 404-412, 2015.
Artículo
en Coreano
| WPRIM
| ID: wpr-205905
ABSTRACT
Glucagon like peptide-1 (GLP-1) is an intestinal L cell derived incretin hormone which stimulates insulin secretion of beta cell and inhibits glucagon secretion of alpha cell of pancreatic islets. GLP-1 receptors are located in pancreas as well as in a wide variety of tissue such as gastrointestinal tract, heart, blood vessel, lung, brain, kidney, and bone. Therefore GLP-1 and GLP-1 based treatment have multiple extrapancreatic effects which are inhibition of gastrointestinal motility, reduction of appetite, weight loss, increase of cardiac output, cardiovascular protection, neuroprotection, renoprotection, and increase of bone mineral density. Recently, besides GLP-1 receptor dependent pathway, GLP-1 receptor independent pathway has been identified in the extrapancreatic effect of GLP-1 in liver, adipose tissue, muscle, cardiovascular system. This review provides an overview of the pleiotropic effect of GLP-1 in the extrapancreatic organ through review of animal and clinical research.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Páncreas
/
Apetito
/
Vasos Sanguíneos
/
Encéfalo
/
Glucagón
/
Gasto Cardíaco
/
Sistema Cardiovascular
/
Pérdida de Peso
/
Densidad Ósea
/
Tejido Adiposo
Límite:
Animales
Idioma:
Coreano
Revista:
Korean Journal of Medicine
Año:
2015
Tipo del documento:
Artículo
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