Analysis of in vitro apoptosis induced by virulent Korean isolate of classical swine fever virus in peripheral blood B cell line / 대한수의학회지
Korean Journal of Veterinary Research
; : 259-262, 2012.
Article
en En
| WPRIM
| ID: wpr-206184
Biblioteca responsable:
WPRO
ABSTRACT
Classical swine fever (CSF) is a highly contagious disease among swine that has an important economic impact on worldwide. One clinical symptom of CSF is leukopenia, in particular lymphopenia, which is a characteristic event that occurs early in the course of CSF. Though lymphopenia associated with apoptosis, the pathogenic mechanism underlying the lymphopenia has not been well studied. To understand these mechanisms, we investigated the response of porcine B cell lines to infection with SW03, virulent strain isolated from swine tissue in Korea. This study demonstrated that SW03-infected L35 cell were induced apoptosis through the detection of activated caspase-3. In addition, SW03 infection leaded to alterations in pro-apoptotic, Bax, and anti-apoptotic, Bcl-xL proteins of Bcl-2 family. Our results would suggest that SW03-infected L35 cells induced apoptosis via intrinsic mitochondrial pathway.
Palabras clave
Texto completo:
1
Índice:
WPRIM
Asunto principal:
Compuestos de Fenilurea
/
Esguinces y Distensiones
/
Porcinos
/
Línea Celular
/
Apoptosis
/
Proteína bcl-X
/
Caspasa 3
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Peste Porcina Clásica
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Virus de la Fiebre Porcina Clásica
/
Corea (Geográfico)
Límite:
Animals
/
Humans
País/Región como asunto:
Asia
Idioma:
En
Revista:
Korean Journal of Veterinary Research
Año:
2012
Tipo del documento:
Article