MYH9 nephropathy
Kidney Research and Clinical Practice
;
: 53-56, 2015.
Artículo
en Inglés
| WPRIM
| ID: wpr-206924
ABSTRACT
MYH9-related disorder is an autosomal dominant disease caused by a mutation in the MYH9 gene, which encodes nonmuscle myosin heavy chain IIA (NMMHC-IIA). This disease is characterized by giant platelets, thrombocytopenia, granulocyte inclusion bodies, proteinuria, and high-pitch sensorineural deafness. Nephropathy has been observed in 30% of patients with MYH9-related disorder. The characteristic features are early onset proteinuria and rapidly progressing renal disorder. However, the prognosis of MYH9 nephropathy remains unclear. Herein, we describe a 36-year-old woman who presented with proteinuria and was diagnosed with MYH9 nephropathy via renal biopsy and gene analysis. Her proteinuria improved after administration of an angiotensin II receptor blocker, but was aggravated after changing to a calcium channel blocker.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Pronóstico
/
Proteinuria
/
Trombocitopenia
/
Biopsia
/
Receptores de Angiotensina
/
Canales de Calcio
/
Cuerpos de Inclusión
/
Cadenas Pesadas de Miosina
/
Sordera
/
Albuminuria
Tipo de estudio:
Estudio pronóstico
Límite:
Adulto
/
Femenino
/
Humanos
Idioma:
Inglés
Revista:
Kidney Research and Clinical Practice
Año:
2015
Tipo del documento:
Artículo
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