A Case of Histiocytic Sarcoma Presenting with Primary Bone Marrow Involvement
Journal of Korean Medical Science
;
: 313-316, 2010.
Artículo
en Inglés
| WPRIM
| ID: wpr-207482
ABSTRACT
Histiocytic sarcoma (HS) is a very rare neoplasm that often shows an aggressive clinical course and systemic symptoms, such as fever, weight loss, adenopathy, hepatosplenomegaly and pancytopenia. It may present as localized or disseminated disease. We describe here a 63-yr-old male who manifested systemic symptoms, including fever, weight loss and generalized weakness. Abdominal and chest computed tomography failed to show specific findings, but there was suspicion of multiple bony changes at the lumbar spine. Fusion whole body positron emission tomography, bone scan and lumbar spine magnetic resonance imaging showed multiple bone lesions, suggesting a malignancy involving the bone marrow (BM). Several BM and bone biopsies were inconclusive for diagnosis. Necropsy showed replacement of the BM by a diffuse proliferation of neoplastic cells with markedly increased cellularity (95%). The neoplastic cells were positive for lysozyme and CD68, but negative for T- and B-cell lineage markers, and megakaryocytic, epithelial, muscular and melanocytic markers. Morphologic findings also distinguished it from other dendritic cell neoplasms.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Médula Ósea
/
Imagen por Resonancia Magnética
/
Antígenos de Diferenciación Mielomonocítica
/
Muramidasa
/
Tomografía Computarizada por Rayos X
/
Antígenos CD
/
Neoplasias de la Médula Ósea
/
Tomografía de Emisión de Positrones
/
Diagnóstico Diferencial
/
Sarcoma Histiocítico
Tipo de estudio:
Estudio diagnóstico
Límite:
Humanos
/
Masculino
Idioma:
Inglés
Revista:
Journal of Korean Medical Science
Año:
2010
Tipo del documento:
Artículo
Similares
MEDLINE
...
LILACS
LIS