Evaluation of interleukin-1beta and 8 in gutka chewers with periodontitis among a rural Indian population
Journal of Periodontal & Implant Science
;
: 126-133, 2014.
Artículo
en Inglés
| WPRIM
| ID: wpr-20881
ABSTRACT
PURPOSE:
Smokeless tobacco-based oral-use products like gutka are popular in India. Gutka usage leads to increased periodontal destruction and inflammation; however, the relevant mechanism remains unknown. This study aimed to elucidate the role of gutka in periodontitis by examining its effect on the levels of interleukin (IL) 1beta and IL-8 from the gingival crevicular fluid (GCF).METHODS:
A total of 45 patients were enrolled in this study. Thirty patients with periodontitis (15 gutka chewers [GCP] and 15 nongutka chewers [NGC]) and 15 periodontally healthy controls (HC) were selected. The full-mouth plaque index (PI), gingival index (GI), probing depth (PD), clinical attachment level (CAL), and recession (RC) were recorded. The IL-1beta and IL-8 levels in the GCF of all subjects were assessed through an enzyme-linked immunosorbent assay (Quantikine).RESULTS:
The IL-1beta and IL-8 levels were not significantly higher in the GCP group (IL-1beta, 369.01+/-273.44 microL; IL-8, 205.97+/-196.78 microL) as compared to those in the NGC group (IL-1beta, 195.57+/-96.85 microL; IL-8, 178.61+/-149.35 microL). More gingival RC and loss of attachment was seen among the GCP group (RC 2.02+/-0.31, P=0.013; CAL 4.60+/-0.56, P<0.001) than among the NGC group (RC, 1.21+/-1.15; CAL, 3.70+/-0.32); however, PD was deeper among the NGC subjects (P=0.002). PI and GI were significantly higher for the periodontitis group (P<0.001) when compared to the HC, but there was no difference among gutka chewers and non-chewers (P=0.22 and P=0.89). A positive correlation was found between the IL-8 levels and the duration of gutka chewing (r=-0.64, P<0.01).CONCLUSIONS:
Gutka chewing leads to increased gingival RC and clinical loss of attachment. There was no effect seen in the proinflammatory cytokine levels in the GCF of gutka users.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Periodontitis
/
Ensayo de Inmunoadsorción Enzimática
/
Índice Periodontal
/
Interleucina-8
/
Líquido del Surco Gingival
/
Interleucinas
/
Tabaco sin Humo
/
Interleucina-1beta
/
India
/
Inflamación
Límite:
Humanos
País/Región como asunto:
Asia
Idioma:
Inglés
Revista:
Journal of Periodontal & Implant Science
Año:
2014
Tipo del documento:
Artículo
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