Thrombotic thrombocytopenic purpura in three pregnancies / 대한산부인과학회지
Korean Journal of Obstetrics and Gynecology
;
: 434-442, 2010.
Artículo
en Coreano
| WPRIM
| ID: wpr-208971
ABSTRACT
Thromobotic thrombocytopenic purpura-hemolytic uremic syndrome (TTP-HUS), characterized by microangiopathic hemolytic anemia, thrombocytopenia, fever, central nervous system abnormalities, and renal dysfunction, is severe multisystem disorder. TTP-HUS occurs predominantly in the reproductive aged-women, associated with poor prognosis. Although the morbidity and mortality have been significantly decreased by using plasma exchange therapy, refractory TTP-HUS remains a tremendous problem. It is crucial to differentiate other microangiopathic hemolytic anemia disease with a confusing presentation and to perform the immediate plasmapheresis. We have experienced three cases, which were initially diagnosed as HELLP syndrome or immune thrombocytopenic purpura. Despite of aggressive plasmapheresis, two women died. We present these cases with a review of the literature on pregnancy-associated thrombotic microangiopathy, including ADAMTS-13 activity assay as a new diagnostic test.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Intercambio Plasmático
/
Preeclampsia
/
Complicaciones del Embarazo
/
Pronóstico
/
Púrpura Trombocitopénica Trombótica
/
Trombocitopenia
/
Sistema Nervioso Central
/
Plasmaféresis
/
Púrpura Trombocitopénica Idiopática
/
Síndrome HELLP
Tipo de estudio:
Estudio pronóstico
Límite:
Femenino
/
Humanos
/
Embarazo
Idioma:
Coreano
Revista:
Korean Journal of Obstetrics and Gynecology
Año:
2010
Tipo del documento:
Artículo
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