A Novel Translocation t(1;5)(p32;q31) that Was Not Associated with the TAL1 Rearrangement in a Case of T Lymphoblastic Leukemia/Lymphoma / 대한진단검사의학회지
The Korean Journal of Laboratory Medicine
;
: 199-203, 2009.
Artículo
en Inglés
| WPRIM
| ID: wpr-208985
ABSTRACT
Chromosome 1 band p32 (1p32) aberrations are common in T lymphoblastic leukemia/lymphoma (T-ALL/LBL). Two types of 1p32 aberrations include translocations with different partners and submicroscopic interstitial deletion. Both aberrations are known to result in TAL1 gene deregulation. The t(1;5)(p32;q31) is a rare translocation of 1p32 in T-ALL. We now present the second case of t(1;5)(p32;q31) in T-ALL, which was present as a primary cytogenetic abnormality, with a review of the relevant literature. Interestingly, neither the translocation of the TAL1 gene nor aberrant expression of TAL1 protein was detected by fluorescent in situ hybridization (FISH) and by immunohistochemical staining in this case.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Translocación Genética
/
Médula Ósea
/
Cromosomas Humanos Par 1
/
Cromosomas Humanos Par 5
/
Tomografía Computarizada por Rayos X
/
Proteínas Proto-Oncogénicas
/
Factores de Transcripción con Motivo Hélice-Asa-Hélice Básico
/
Leucemia-Linfoma Linfoblástico de Células T Precursoras
/
Cariotipificación
Límite:
Humanos
/
Masculino
Idioma:
Inglés
Revista:
The Korean Journal of Laboratory Medicine
Año:
2009
Tipo del documento:
Artículo
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