Up-regulation of RhoGDI2 in Human Breast Cancer and Its Prognostic Implications / Journal of the Korean Cancer Association, 대한암학회지
Cancer Research and Treatment
;
: 151-156, 2010.
Artículo
en Inglés
| WPRIM
| ID: wpr-209011
ABSTRACT
PURPOSE:
Recent research has identified many genes and proteins that play specific roles in the process of systemic metastasis in various types of cancer. Rho GDP dissociation inhibitor 2 (RhoGDI2) has been shown to inhibit metastasis in human bladder cancer, but its role in breast cancer is controversial. MATERIALS ANDMETHODS:
We examined the regulation and clinical significance of RhoGDI2 in Korean breast cancer patients by using proteomic approaches.RESULTS:
By using a proteomic approach, we observed an increased expression of RhoGDI2 in human breast cancer tissues when compared to that of the normal breast tissues, and we validated its up-regulation in an independent cohort of 8 breast cancer patients. The clinical implication of a RhoGDI2 expression was investigated in 57 breast cancer patients by performing immunohistochemistry. RhoGDI2 did not show a significant association with the tumor size, lymph node metastasis, the histologic grade or the hormone receptor status. However, the patients with RhoGDI2-expressing tumors had significantly shorter disease-free survival (p=0.043; hazard ratio, 3.87) and distant metastasis-free survival (p=0.039; hazard ratio, 5.15).CONCLUSION:
Our results demonstrated a potential role of RhoGDI2 as a poor prognostic marker as well as a potential therapeutic target. The pro-metastatic nature of RhoGDI2 shown in our study may indicate its organ-specific role in cancer metastasis.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Pronóstico
/
Neoplasias de la Vejiga Urinaria
/
Mama
/
Neoplasias de la Mama
/
Inmunohistoquímica
/
Proteínas
/
Regulación hacia Arriba
/
Estudios de Cohortes
/
Supervivencia sin Enfermedad
/
Proteómica
Tipo de estudio:
Estudio de etiología
/
Estudio de incidencia
/
Estudio observacional
/
Estudio pronóstico
/
Factores de riesgo
Límite:
Humanos
Idioma:
Inglés
Revista:
Cancer Research and Treatment
Año:
2010
Tipo del documento:
Artículo
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