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Multiple Intracranial Tuberculomas Mimicking Granulocytic Sarcomas in Acute Myeloid Leukemia
Journal of Korean Medical Science ; : S171-S173, 2007.
Artículo en Inglés | WPRIM | ID: wpr-209036
ABSTRACT
The diagnosis of incracranial tuberculoma in immune-compromised hosts is often difficult because conventional magnetic resonance (MR) imaging of tuberculoma reveals various findings and neurologic symptoms are not typical. Here, we report a case of a 54-yr old man with multiple intracranial tuberculoma who was treated for acute myeloid leukemia. He complained of right-side paresthesia after the third consolidation chemotherapy without leukemic relapse and fever. MR imaging of the brain showed multiple ring-enhanced lesions in the cerebrum, cerebellar hemisphere, and pons. The lesions appeared to mimic a metastatic tumor or abscess. Cerebrospinal fluid analysis showed no abnormal cells, but the level of adenosine deaminase was elevated (28.8 IU/L, normal 0-8). Stereotactic brain biopsy was performed, but only reactive gliosis was observed. To confirm diagnosis, an open brain biopsy was performed. The histopathology demonstrated chronic granulomatous inflammation with caseous necrosis. Tuberculous-polymerase chain reaction of the biopsy showed a positive result. He was treated with anti-tuberculosis medication and a high dose of steroid. Paresthesia improved, and follow-up brain MR imaging showed the decreased size and numbers of ring-enhanced lesions and improvement of perilesional edema 1 month after treatment. Here, we report on an interesting case of intracranial tuberculoma in acute myeloid leukemia.
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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Neoplasias Encefálicas / Imagen por Resonancia Magnética / Leucemia Mieloide Aguda / Tuberculoma Intracraneal / Sarcoma Mieloide / Diagnóstico Diferencial / Antituberculosos Tipo de estudio: Estudio diagnóstico Límite: Humanos / Masculino Idioma: Inglés Revista: Journal of Korean Medical Science Año: 2007 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Neoplasias Encefálicas / Imagen por Resonancia Magnética / Leucemia Mieloide Aguda / Tuberculoma Intracraneal / Sarcoma Mieloide / Diagnóstico Diferencial / Antituberculosos Tipo de estudio: Estudio diagnóstico Límite: Humanos / Masculino Idioma: Inglés Revista: Journal of Korean Medical Science Año: 2007 Tipo del documento: Artículo