Functional Regulation of Dopamine D₃ Receptor through Interaction with PICK1
Biomolecules & Therapeutics
;
: 475-481, 2016.
Artículo
en Inglés
| WPRIM
| ID: wpr-209246
ABSTRACT
PICK1, a PDZ domain-containing protein, is known to increase the reuptake activities of dopamine transporters by increasing their expressions on the cell surface. Here, we report a direct and functional interaction between PICK1 and dopamine D₃ receptors (D₃R), which act as autoreceptors to negatively regulate dopaminergic neurons. PICK1 colocalized with both dopamine D₂ receptor (D₂R) and D₃R in clusters but exerted different functional influences on them. The cell surface expression, agonist affinity, endocytosis, and signaling of D₂R were unaffected by the coexpression of PICK1. On the other hand, the surface expression and tolerance of D₃R were inhibited by the coexpression of PICK1. These findings show that PICK1 exerts multiple effects on D₃R functions.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Dopamina
/
Autorreceptores
/
Endocitosis
/
Proteínas de Transporte de Dopamina a través de la Membrana Plasmática
/
Neuronas Dopaminérgicas
/
Mano
Idioma:
Inglés
Revista:
Biomolecules & Therapeutics
Año:
2016
Tipo del documento:
Artículo
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