Changes in serum uric acid levels after allogeneic hematologic stem cell transplantation: A retrospective cohort study
Blood Research
;
: 200-203, 2016.
Artículo
en Inglés
| WPRIM
| ID: wpr-209252
ABSTRACT
BACKGROUND:
Since cell turnover in the hematopoietic system constitutes a major source of uric acid (UA) production, we investigated whether hematopoietic stem cell transplantation (HSCT) is associated with significant changes in serum UA levels in patients with hematological disorders.METHODS:
Patients who underwent HSCT at our institution between 2001 and 2012 were retrospectively enrolled. Serum UA levels at 3 months before, 1 week before, and 3 months and 1 year after HSCT were examined.RESULTS:
Complete clinical and laboratory information including data regarding UA levels was available for 93 patients. At baseline, the mean UA level was 4.9±2.1 mg/dL, with an overall prevalence of hyperuricemia of 15% (defined as serum UA>6.8 mg/dL). Mean UA levels tended to be higher in patients with acute myeloid leukemia (4.8±2.0 mg/dL) and non-Hodgkin lymphoma (5.1±2.3 mg/dL) and lower in patients with aplastic anemia (mean, 4.2±1.8 mg/dL). UA levels dropped during myeloablative conditioning, reaching a nadir on the day of HSCT (3.27±1.4 mg/dL). Over the 3 months following HSCT, UA levels rose sharply (5.0±2.1 mg/dL) and remained stable up to 1 year after HSCT (5.5±1.6 mg/dL). UA levels in HSCT recipients at 12 months correlated with those of their respective graft donors (Pearson r=0.406, P=0.001).CONCLUSION:
HSCT is associated with significant changes in uric acid levels in patients with hematologic disorders.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Células Madre
/
Donantes de Tejidos
/
Ácido Úrico
/
Médula Ósea
/
Linfoma no Hodgkin
/
Leucemia Mieloide Aguda
/
Prevalencia
/
Estudios Retrospectivos
/
Estudios de Cohortes
/
Trasplante de Células Madre Hematopoyéticas
Tipo de estudio:
Estudio de etiología
/
Estudio de incidencia
/
Estudio observacional
/
Estudio de prevalencia
/
Factores de riesgo
Límite:
Humanos
Idioma:
Inglés
Revista:
Blood Research
Año:
2016
Tipo del documento:
Artículo
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