Detection of MYD88 L265P in patients with lymphoplasmacytic lymphoma/Waldenstrom macroglobulinemia and other B-cell non-Hodgkin lymphomas
Blood Research
;
: 181-186, 2016.
Artículo
en Inglés
| WPRIM
| ID: wpr-209255
ABSTRACT
BACKGROUND:
Recent studies have identified a high prevalence of the MYD88 L265P mutation in lymphoplasmacytic lymphoma (LPL)/Waldenstrom macroglobulinemia (WM) cases, whereas low frequencies have been observed in other B cell non-Hodgkin lymphomas (NHLs).METHODS:
We evaluated the sensitivity of the mutant enrichment 3'-modified oligonucleotide (MEMO)-PCR technique, a new detection method. We examined the MYD88 L265P mutation in a series of Korean patients with LPL/WM and other B cell NHLs in bone marrow aspirates, using the MEMO-PCR technique.RESULTS:
The sensitivity of MEMO-PCR was estimated to be approximately 10-16.7%. MYD88 L265P was detected in 21 of 28 LPL cases (75%) and only three of 69 B cell NHL cases (4.3%).CONCLUSION:
Although MEMO-PCR had relatively low sensitivity, we confirmed the high prevalence of the MYD88 L265P mutation in Korean LPL patients. Our study suggests the diagnostic value of MYD88 L265P for differentiating B-cell NHLs.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Médula Ósea
/
Linfoma no Hodgkin
/
Linfocitos B
/
Prevalencia
/
Macroglobulinemia de Waldenström
/
Linfoma
/
Métodos
Tipo de estudio:
Estudio diagnóstico
/
Estudio de prevalencia
Límite:
Humanos
Idioma:
Inglés
Revista:
Blood Research
Año:
2016
Tipo del documento:
Artículo
Similares
MEDLINE
...
LILACS
LIS