Effects of Chitosan on the Differentiation of MDPC-23 Cells
International Journal of Oral Biology
;
: 91-97, 2010.
Artículo
en Coreano
| WPRIM
| ID: wpr-209528
ABSTRACT
The effects of chitosan upon the experimentally induced differentiation of MDPC-23 cells, derived from mouse dental papilla cells, were investigated by RT-PCR, observations of cell morphology and Alizaline red-S staining. Chitosan was found to significantly increase and accelerate the expression of ALP mRNA but decrease the ColI transcript levels, as compared with the control, in a time-dependent manner during the differentiation of MDPC-23 cells. Chitosan also significantly downregulated ON mRNA expression and accelerated mineralization in differentiating MDPC-23 cells. These results suggest that chitosan facilitates odontoblast differentiation and mineralization and may have potential clinical applications as a dentin regeneration material.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Regeneración
/
ARN Mensajero
/
Papila Dental
/
Dentina
/
Quitosano
/
Odontoblastos
Límite:
Animales
Idioma:
Coreano
Revista:
International Journal of Oral Biology
Año:
2010
Tipo del documento:
Artículo
Similares
MEDLINE
...
LILACS
LIS