Diencephalic syndrome: a frequently neglected cause of failure to thrive in infants / 소아과
Korean Journal of Pediatrics
;
: 28-32, 2015.
Artículo
en Inglés
| WPRIM
| ID: wpr-209588
ABSTRACT
PURPOSE:
Diencephalic syndrome is an uncommon cause of failure to thrive in early childhood that is associated with central nervous system neoplasms in the hypothalamic-optic chiasmatic region. It is characterized by complex signs and symptoms related to hypothalamic dysfunction; such nonspecific clinical features may delay diagnosis of the brain tumor. In this study, we analyzed a series of cases in order to define characteristic features of diencephalic syndrome.METHODS:
We performed a retrospective study of 8 patients with diencephalic syndrome (age, 5-38 months). All cases had presented to Seoul National University Children's Hospital between 1995 and 2013, with the chief complaint of poor weight gain.RESULTS:
Diencephalic syndrome with central nervous system (CNS) neoplasm was identified in 8 patients. The mean age at which symptoms were noted was 18+/-10.5 months, and diagnosis after symptom onset was made at the mean age of 11+/-9.7 months. The mean z score was -3.15+/-1.14 for weight, -0.12+/-1.05 for height, 1.01+/-1.58 for head circumference, and -1.76+/-1.97 for weight-for-height. Clinical features included failure to thrive (n=8), hydrocephalus (n=5), recurrent vomiting (n=5), strabismus (n=2), developmental delay (n=2), hyperactivity (n=1), nystagmus (n=1), and diarrhea (n=1). On follow-up evaluation, 3 patients showed improvement and remained in stable remission, 2 patients were still receiving chemotherapy, and 3 patients were discharged for palliative care.CONCLUSION:
Diencephalic syndrome is a rare cause of failure to thrive, and diagnosis is frequently delayed. Thus, it is important to consider the possibility of a CNS neoplasm as a cause of failure to thrive and to ensure early diagnosis.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Cuidados Paliativos
/
Astrocitoma
/
Vómitos
/
Neoplasias Encefálicas
/
Aumento de Peso
/
Sistema Nervioso Central
/
Estrabismo
/
Estudios Retrospectivos
/
Estudios de Seguimiento
/
Neoplasias del Sistema Nervioso Central
Tipo de estudio:
Estudio diagnóstico
/
Estudio observacional
/
Estudio pronóstico
/
Estudio de tamizaje
Límite:
Humanos
/
Lactante
País/Región como asunto:
Asia
Idioma:
Inglés
Revista:
Korean Journal of Pediatrics
Año:
2015
Tipo del documento:
Artículo
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