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Concentration of Vascular Endothelial Growth Factor After Intracameral Bevacizumab Injection in Eyes With Neovascular Glaucoma
Korean Journal of Ophthalmology ; : 188-192, 2009.
Artículo en Inglés | WPRIM | ID: wpr-210146
ABSTRACT

PURPOSE:

To study the concentration of vascular endothelial growth factor (VEGF) in the aqueous humor before and after intracameral injection of bevacizumab in eyes with neovascular glaucoma, and to detect the duration of an anti-VEGF effect of bevacizumab in the anterior chamber.

METHODS:

In this prospective interventional case series, 1.25 mg of bevacizumab was injected into the anterior chamber of five eyes in five neovascular glaucoma patients. Aqueous humor samples were obtained just before intracameral injection of bevacizumab and two weeks after injection. The concentrations of VEGF in the aqueous humor were measured using ELISA. To investigate corneal endothelial damage after intrecameral bevacizumab injection, specular microscopy was performed before injection and two weeks after injection. Slit lamp photo and iris fluorescent angiography was performed to determine the regression of iris neovascularization.

RESULTS:

After injection, substantial regression of neovascularization or fluorescein leakage was seen in all treated eyes. The VEGF concentrations in the aqueous humor in eyes with NVG were 1181.8+/-1248.3 pg/mL before intracameral injection of bevacizumab. Two weeks after injection, the VEGF concentrations decreased to 33.2+/-12.2 pg/mL (p=0.04, Wilcoxon signed rank test). There were no significant changes in IOP or corneal endothelial cells.

CONCLUSIONS:

Intracameral bevacizumab injection can remarkably reduce iris neovascularization in neovascular glaucoma patients. VEGF levels were significantly decreased two weeks after injection and corneal toxicity was not observed during short term follow-up.
Asunto(s)

Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Concentración Osmolar / Humor Acuoso / Glaucoma Neovascular / Estudios Prospectivos / Inhibidores de la Angiogénesis / Factor A de Crecimiento Endotelial Vascular / Ojo / Inyecciones / Anticuerpos Monoclonales Tipo de estudio: Estudio observacional Límite: Adulto / Anciano / Aged80 / Humanos Idioma: Inglés Revista: Korean Journal of Ophthalmology Año: 2009 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Concentración Osmolar / Humor Acuoso / Glaucoma Neovascular / Estudios Prospectivos / Inhibidores de la Angiogénesis / Factor A de Crecimiento Endotelial Vascular / Ojo / Inyecciones / Anticuerpos Monoclonales Tipo de estudio: Estudio observacional Límite: Adulto / Anciano / Aged80 / Humanos Idioma: Inglés Revista: Korean Journal of Ophthalmology Año: 2009 Tipo del documento: Artículo