Predictive Value of Antiviral Effects in the Development of Hepatocellular Carcinoma in the General Korean Population with Chronic Hepatitis B
Gut and Liver
;
: 962-968, 2016.
Artículo
en Inglés
| WPRIM
| ID: wpr-210172
ABSTRACT
BACKGROUND/AIMS:
The benefit of oral antiviral therapy in preventing hepatocellular carcinoma (HCC) in the general population is not well understood. We used a novel prediction method to estimate the risk of HCC in the Korean population based on various treatment guidelines.METHODS:
The 5-year risk of HCC following antiviral therapy was calculated using an HCC risk prediction model. A virtual cohort that represented Koreans (>40 years old) with chronic hepatitis B virus (HBV) infection was established using the fifth National Health and Nutrition Examination Survey. The antiviral indications tested were the Korean National Health Insurance (NHI) and European Association for the Study of the Liver (EASL) guidelines as well as a new extended indication (serum HBV DNA >2,000 IU/mL regardless of serum aminotransferase level).RESULTS:
A total of 993,872 subjects were infected with HBV in the general Korean population. Over a 5-year period, 2,725 HCC cases were predicted per 100,000 persons (0.55%/yr). When the cohort was treated based on the Korean NHI, the EASL, and the newly extended indications, HCC risks decreased to 2,531 (−7.1%), 2,089 (−23.3%), and 1,122 (−58.8%) cases per 100,000 persons, respectively (p<0.0001).CONCLUSIONS:
Simulated risk prediction suggests that extending of oral antiviral indication may reduce the HCC risk in the general population.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
ADN
/
Encuestas Nutricionales
/
Estudios de Cohortes
/
Carcinoma Hepatocelular
/
Hepatitis B Crónica
/
Hepatitis Crónica
/
Hígado
/
Métodos
/
Programas Nacionales de Salud
Tipo de estudio:
Estudio de etiología
/
Guía de Práctica Clínica
/
Estudio de incidencia
/
Estudio observacional
/
Estudio pronóstico
/
Investigación cualitativa
/
Factores de riesgo
Límite:
Humanos
Idioma:
Inglés
Revista:
Gut and Liver
Año:
2016
Tipo del documento:
Artículo
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