Micro-CT Evaluation in Osteoporosis Model / 체질인류학회지
Korean Journal of Physical Anthropology
;
: 283-290, 2005.
Artículo
en Coreano
| WPRIM
| ID: wpr-210565
ABSTRACT
Osteoporosis is a major health-care problem for aging communities. And postmenopausal osteoporosis is a common disorder characterized by an increase in bone resorption relative to bone formation, generally in conjunction with an increased rate of bone turnover. Twenty female rats were used as rat model of osteoporosis. They randomly were divided into two groups a normal control group, and calcium-free diet groups treated with bilateral ovariectomy. The animals were sacrified at 12 weeks after treatment. In the rats with osteoporosis, there was significant thining and loss of trabeculae, accompanied by a disconnection of trabeculae. And acid mucopolysaccharides were decreased in osteoporotic animals. In order to setup conditions of invivo micro-CT, proper anesthetic is ketamine (50 mg/kg) /xylazine (6 mg/kg). And proper breathing rate of experimental animals is 1.3~1.6/sec. Our finding suggest that bilateral ovariectomy and calcium-free diet induce decrease in thickeness of trabecular bone and decrease in acid mucopolysaccharide, therefore cause weakness of bone. And micro-CT imaging system is useful to evaluate trabecular bone. Anesthetic time, anesthetics and respiration rate also signify much in micro-CT imaging system.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Osteogénesis
/
Osteoporosis
/
Respiración
/
Resorción Ósea
/
Envejecimiento
/
Ovariectomía
/
Osteoporosis Posmenopáusica
/
Modelos Animales
/
Dieta
/
Frecuencia Respiratoria
Tipo de estudio:
Estudio pronóstico
Límite:
Animales
/
Femenino
/
Humanos
Idioma:
Coreano
Revista:
Korean Journal of Physical Anthropology
Año:
2005
Tipo del documento:
Artículo
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