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Pathologic Outcomes in Men with Low-risk Prostate Cancer Who Are Potential Candidates for Contemporary, Active Surveillance Protocols
Journal of Korean Medical Science ; : 932-936, 2015.
Artículo en Inglés | WPRIM | ID: wpr-210691
ABSTRACT
The purpose of this study was to determine whether contemporary active surveillance (AS) protocols could sufficiently discriminate significant from indolent tumors in men with low-risk prostate cancer. We retrospectively analyzed 312 patients with low-risk prostate cancer treated with radical prostatectomy. After exclusion of patients with fewer than 10 cores taken at biopsy and those who received neo-adjuvant treatment, 205 subjects satisfied the final inclusion criteria. Five widely accepted AS protocols were employed in this study. A total of 82.0% of the patients met the inclusion criteria of at least one protocol, and 18% did not meet any criteria of published AS protocols. A significant proportion of patients had non-organ-confined disease (8.6% to 10.6%) or a Gleason score of 7 or greater (18.6% to 23.9%) between the different AS criteria. Among patients who did not meet any AS criteria, 32.4% of patients had a pathologically insignificant cancer. Our results indicated a significant adverse pathology in patients who met the contemporary AS protocols. On the other hand, some patients in whom expectant management would be appropriate did not meet any criteria of published AS protocols. None of the clinical or histological criteria reported to date is able to sufficiently discriminate aggressive tumors from indolent ones.
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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Próstata / Prostatectomía / Neoplasias de la Próstata / Calicreínas / Estudios Retrospectivos / Resultado del Tratamiento / Antígeno Prostático Específico / Medición de Riesgo / Espera Vigilante / Clasificación del Tumor Tipo de estudio: Estudio de etiología / Guía de Práctica Clínica / Estudio observacional / Factores de riesgo / Estudio de tamizaje Límite: Anciano / Humanos / Masculino Idioma: Inglés Revista: Journal of Korean Medical Science Año: 2015 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Próstata / Prostatectomía / Neoplasias de la Próstata / Calicreínas / Estudios Retrospectivos / Resultado del Tratamiento / Antígeno Prostático Específico / Medición de Riesgo / Espera Vigilante / Clasificación del Tumor Tipo de estudio: Estudio de etiología / Guía de Práctica Clínica / Estudio observacional / Factores de riesgo / Estudio de tamizaje Límite: Anciano / Humanos / Masculino Idioma: Inglés Revista: Journal of Korean Medical Science Año: 2015 Tipo del documento: Artículo