Apolipoprotein E Polymorphism in Schizophrenic Patients / 신경정신의학
Journal of Korean Neuropsychiatric Association
;
: 503-509, 2001.
Artículo
en Coreano
| WPRIM
| ID: wpr-211113
ABSTRACT
OBJECTIVES:
To explore the role of apolipoprotein E in schizophrenia, we investigated apoli-poprotein E polymorphism in groups of patients with schizophrenia and normal controls. We also examined the relationship of clinical characteristics of schizophrenia to apolipoprotein E genotypes.METHODS:
Samples were obtained from 101 schizophrenic patients and 96 controls in Korea and apolipoprotein E polymorphisms were analysed using polymerase chain reaction.RESULTS:
The genotype and allele frequencies did not differ from those of controls. The clinical variables of schizophrenia, such as positive and negative groups by PANSS, subtypes by DSM-IV, family history were not associated with each genotypes.CONCLUSION:
We could not find the association of apolipoprotein E in Korean schizophrenic patients and it could be suggested that apolipoprotein E isoforms might not play a main role in expression of schizophrenia.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Apolipoproteínas
/
Esquizofrenia
/
Reacción en Cadena de la Polimerasa
/
Isoformas de Proteínas
/
Manual Diagnóstico y Estadístico de los Trastornos Mentales
/
Frecuencia de los Genes
/
Genotipo
/
Corea (Geográfico)
Límite:
Humanos
País/Región como asunto:
Asia
Idioma:
Coreano
Revista:
Journal of Korean Neuropsychiatric Association
Año:
2001
Tipo del documento:
Artículo
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