Biomarkers Predicting Alzheimer's Disease in Cognitively Normal Aging
Journal of Clinical Neurology
;
: 60-68, 2011.
Artículo
en Inglés
| WPRIM
| ID: wpr-211525
ABSTRACT
The pathophysiologic process of Alzheimer's disease (AD) begins years before the diagnosis of clinical dementia. This concept of preclinical AD has arisen from the observation of AD pathologic findings such as senile plaques and neurofibrillary tangles in the brains of people who at the time of death had normal cognitive function. Recent advances in biomarker studies now provide the ability to detect the pathologic changes of AD, which are antecedent to symptoms of the illness, in cognitively normal individuals. Functional and structural brain alterations that begin with amyloid-beta accumulation already show the patterns of abnormality seen in individuals with dementia due to AD. The presence of preclinical AD provides a critical opportunity for potential interventions with disease-modifying therapy. This review focuses on the studies of antecedent biomarkers for preclinical AD.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Encéfalo
/
Envejecimiento
/
Biomarcadores
/
Ovillos Neurofibrilares
/
Placa Amiloide
/
Demencia
/
Enfermedad de Alzheimer
Tipo de estudio:
Estudio pronóstico
Idioma:
Inglés
Revista:
Journal of Clinical Neurology
Año:
2011
Tipo del documento:
Artículo
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