Morphology and Function of Testis in Growth Deprived Mature and Immature Male Rats / 대한비뇨기과학회지
Korean Journal of Urology
;
: 357-364, 1994.
Artículo
en Coreano
| WPRIM
| ID: wpr-212108
ABSTRACT
Growth hormone(GH) plays a major role in growth and its effects are mainly mediated by insulin like growth factor-I ( IGF-I). However the role of GH in the regulation of testicular function especially in spermatogenesis is still under debate. Though there were several studies using GH-deficient mutant mice, results are conflicting. Furthermore they are not proper to find out any exact role of GH in normal adults. We have therefore used somatostatin analogue (Sandostatin) for 1 week to block the effect of GH and it's mediator IGF-I, in mature and immature Sprague-Dawley male rats. In immature rats the delayed maturation was recovered after ceasing somatostatin in several weeks and the testicular parameters became normal after maturation. Post-pubertal rats showed diminished spermatogenesis especially in the number of pachytene spermatocytes and round spermatids of stage VII. These results seems to be associated with decreased systemic IGF-I. But the Leydig cell function in other words, testosterone production, remained normal. Somatostatin administered Leydig cells showed strong positive reactions like normal control on IGF-I immunohistochemical stain. We concluded that GH mediated IGF-I plays a major role in spermatogenesis especially on pachytene spermatocytes of post-pubertal male rats and there are GH independent IGF-I actions in Leydig cells.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Espermátides
/
Espermatocitos
/
Espermatogénesis
/
Testículo
/
Testosterona
/
Factor I del Crecimiento Similar a la Insulina
/
Somatostatina
/
Ratas Sprague-Dawley
/
Insulina
/
Células Intersticiales del Testículo
Límite:
Animales
/
Humanos
/
Masculino
Idioma:
Coreano
Revista:
Korean Journal of Urology
Año:
1994
Tipo del documento:
Artículo
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