Surgical Treatment of Primary Neuroendocrine Tumors of the Liver
Korean Journal of Hepato-Biliary-Pancreatic Surgery
;
: 48-53, 2007.
Artículo
en Coreano
| WPRIM
| ID: wpr-212141
ABSTRACT
PURPOSE:
Primary neuroendocrine tumor (PNET) of the liver is a very rare neoplasm. This study was conducted to analyze the clinical experience of 8 hepatic PNET cases.METHODS:
Four male and 4 female patients with a mean age of 50.4 +/- 9.5 years (range 37-64 years) underwent liver resection for hepatic PNET between January 1997 and December 2006. The diagnosis was confirmed histologically using light microscopy and immunohistochemistry in the absence of an alternative primary siteRESULTS:
Curative resection was achieved in 6 of the 8 patients, and 5 of the patients were alive and disease free after a mean follow-up period of 47.6 months. However, 3 patients died 3, 5 and 26 months after surgery due to multiple liver metastasis. A proliferative index of Ki67 appeared to indicate a significant risk factor for tumor recurrence. Additionally, recurrence occurred in 1 of the 6 patients that underwent curative resection during the follow-up period. Overall, both the 5-year recurrence rate and the 5-year survival rate were 50%.CONCLUSIONS:
Active exclusion of an extrahepatic primary site is essential for diagnosis of hepatic PNET. The primary treatment for PNET is curative liver resection, and a proliferative index of Ki67 appears to be a prognostic factor for tumor recurrence.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Recurrencia
/
Inmunohistoquímica
/
Tumor Carcinoide
/
Tasa de Supervivencia
/
Factores de Riesgo
/
Estudios de Seguimiento
/
Tumores Neuroendocrinos
/
Tumores Neuroectodérmicos Primitivos
/
Diagnóstico
/
Hígado
Tipo de estudio:
Estudio diagnóstico
/
Estudio de etiología
/
Estudio observacional
/
Estudio pronóstico
/
Factores de riesgo
Límite:
Femenino
/
Humanos
/
Masculino
Idioma:
Coreano
Revista:
Korean Journal of Hepato-Biliary-Pancreatic Surgery
Año:
2007
Tipo del documento:
Artículo
Similares
MEDLINE
...
LILACS
LIS