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Study on Association between Single Nucleotide Polymorphisms of MMP7, MMP8, MMP9 Genes and Development of Gastric Cancer and Lymph Node Metastasis / 대한소화기학회지
The Korean Journal of Gastroenterology ; : 245-251, 2011.
Artículo en Coreano | WPRIM | ID: wpr-212482
ABSTRACT
BACKGROUND/

AIMS:

Matrix metallopeptidase (MMP) is known to be involved in tumor invasion and metastasis of cancer. This study investigated the association of MMP7 rs11568818, MMP8 rs11225395, MMP9 rs17576 and rs2250889 with gastric cancer (GC) development and lymph node metastasis (LNM).

METHODS:

Samples were obtained from 326 chronic gastritis (CG) and 153 GC patients and genotyped by using the GoldenGate(R) method. Chi-square test was performed to identify the difference of allele distribution between each group (CG vs. GC; CG vs. with LNM GC). The associations of genotype with risk of GC and LNM were estimated by odds ratio and the 95% confidence interval was calculated by logistic regression adjusting for age and sex.

RESULTS:

The allele and genotype frequencies of MMP7 rs11568818, MMP8 rs11225395, MMP9 rs17576 and rs2250889 were not associated with the development of GC and LNM.

CONCLUSIONS:

In summary, MMP7 rs11568818, MMP8 rs11225395 MMP9 rs17576 and rs2250889 were not associated with the GC development and LNM in Korean population.
Asunto(s)

Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Neoplasias Gástricas / Modelos Logísticos / Oportunidad Relativa / Factores Sexuales / Enfermedad Crónica / Factores de Riesgo / Factores de Edad / Metaloproteinasa 9 de la Matriz / Metaloproteinasa 8 de la Matriz / Metaloproteinasa 7 de la Matriz Tipo de estudio: Estudio de etiología / Estudio pronóstico / Factores de riesgo Límite: Adulto / Anciano / Femenino / Humanos / Masculino Idioma: Coreano Revista: The Korean Journal of Gastroenterology Año: 2011 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Neoplasias Gástricas / Modelos Logísticos / Oportunidad Relativa / Factores Sexuales / Enfermedad Crónica / Factores de Riesgo / Factores de Edad / Metaloproteinasa 9 de la Matriz / Metaloproteinasa 8 de la Matriz / Metaloproteinasa 7 de la Matriz Tipo de estudio: Estudio de etiología / Estudio pronóstico / Factores de riesgo Límite: Adulto / Anciano / Femenino / Humanos / Masculino Idioma: Coreano Revista: The Korean Journal of Gastroenterology Año: 2011 Tipo del documento: Artículo