The Effects of Dimethly Sulfoxide and Sodium thiosulfate for the Prevention of Tissue Necrosis due to Extravasation of Mitomycin-C / 영남의대학술지
Yeungnam University Journal of Medicine
;
: 243-250, 1996.
Artículo
en Coreano
| WPRIM
| ID: wpr-213076
ABSTRACT
Extravasation of toxic chemotherapeutic 'agents cause severe skin ulceration and necrosis which often need secondary surgical intervention. Still, there were not established antidote agent in case of extravasation with mitomycin-c. Dimethyl sulfoxide is known as an effective chemical scavenger of toxic hydroxyl free radical and sodium thiosulfate also was demonstrated significant protector from mitomycin-c induced ulceration by a few experimental studies. Author investigated necrotic area of mitomycin-c injected site and compare to the effectiveness of topical treatment with dimethyl sulfoxide and intradermal injection of sodium thiosulfate according to starting times, forty five mice were divided into 3 groups. Control group(n=5) had no treatment after subcutaneous injection of mitomycin-c. Experimental group I and 11 were 20 mice treated dimethyl sulfoxide and sodium.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Úlcera Cutánea
/
Sodio
/
Úlcera
/
Inyecciones Intradérmicas
/
Dimetilsulfóxido
/
Mitomicina
/
Inyecciones Subcutáneas
/
Necrosis
Límite:
Animales
Idioma:
Coreano
Revista:
Yeungnam University Journal of Medicine
Año:
1996
Tipo del documento:
Artículo
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