The Effect of Timing of Ondansetron Administration on Nausea and Vomiting during Intravenous Patient-Controlled Analgesia / 대한마취과학회지
Korean Journal of Anesthesiology
;
: 33-38, 2001.
Artículo
en Coreano
| WPRIM
| ID: wpr-213448
ABSTRACT
BACKGROUND:
This study was designed to establish the optimal timing of administration of ondansetron for prevention of postoperative nausea and vomiting (PONV) during intravenous patient-controlled analgesia (IV-PCA).METHODS:
Eighty women undergoing a total abdominal hysterectomy under general anesthesia were randomized to receive a placebo (n = 20, group 1), ondansetron 2 mg before induction and 2 mg after surgery (n = 20, group 2), ondansetron 4 mg before induction (n = 20, group 3), or ondansetron 4 mg after surgery (n = 20, group 4). An IV-PCA using butorphanol and ketorolac was connected to the patients after waking from the anesthesia. The incidences and severity of nausea and vomiting were recorded for 48 hr postop.RESULTS:
The incidences of nausea and vomiting in group 1 (75%, 40%) were significantly decreased after ondansetron administration but there were no significant differences among the ondansetron groups (group 2; 45%, 20%, group 3; 45%, 15%, group 4; 40%, 10%) (P < 0.05).CONCLUSIONS:
The prophylactic administration of ondansetron is effective in preventing PONV during IV-PCA, but the timing of ondansetron administration has no effect on its efficacy.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Vómitos
/
Butorfanol
/
Incidencia
/
Analgesia Controlada por el Paciente
/
Ondansetrón
/
Náusea y Vómito Posoperatorios
/
Ketorolaco
/
Histerectomía
/
Anestesia
/
Anestesia General
Tipo de estudio:
Ensayo Clínico Controlado
/
Estudio de incidencia
/
Estudio pronóstico
Límite:
Femenino
/
Humanos
Idioma:
Coreano
Revista:
Korean Journal of Anesthesiology
Año:
2001
Tipo del documento:
Artículo
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