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Expression of c-erbB-2 Oncoprotein and DNA Topoisomerase II-alpha in Premalignant Lesions and Invasive Squamous Cell Carcinomas of the Uterine Cervix / 대한산부인과학회잡지
Korean Journal of Obstetrics and Gynecology ; : 2124-2129, 2002.
Artículo en Coreano | WPRIM | ID: wpr-213717
ABSTRACT

OBJECTIVE:

The relationship was studied between expression of c-erbB-2 oncoprotein and topoisomerase II-alpha as proliferating marker in precancerous lesions and invasive squamous carcinomas of the uterine cervix.

METHODS:

Total 81 formalin-fixed, paraffin-embedded sections of low-grade intrasquamous lesion (22 cases), high-grade intraepithelial lesions (42 cases) and invasive squamous cell carcinomas (17 cases) in the uterine cervix were stained by immunohistochemistry for expression of the c-erbB-2 oncoprotein and topoisomerase II-alpha.

RESULTS:

The expression of c-erbB-2 oncoprotein and staining index (mean+/-S.D) of topoisomerase II-alpha were statistically significant between precancerous lesions and invasive carcinoma. The expression of c-erbB-2 oncoprotein has correlation with staining index (mean+/-S.D) of topoisomerase II-alpha.

CONCLUSION:

There results suggest that the expression of c-erbB-2 protein has relationship with progression of squamous lesions and topoisomerase II-alpha is an useful proliferating marker in the uterine cervix. And, the expression of c-erbB-2 protein has correlation with expression of topoisomerase II-alpha.
Asunto(s)

Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: ADN / Inmunohistoquímica / Carcinoma de Células Escamosas / Cuello del Útero / ADN-Topoisomerasas de Tipo I / Receptor ErbB-2 Idioma: Coreano Revista: Korean Journal of Obstetrics and Gynecology Año: 2002 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: ADN / Inmunohistoquímica / Carcinoma de Células Escamosas / Cuello del Útero / ADN-Topoisomerasas de Tipo I / Receptor ErbB-2 Idioma: Coreano Revista: Korean Journal of Obstetrics and Gynecology Año: 2002 Tipo del documento: Artículo