Enhanced expression of cathepsin L in metastatic bone tumors
Journal of Korean Medical Science
;
: 144-148, 1996.
Artículo
en Inglés
| WPRIM
| ID: wpr-214273
ABSTRACT
Cathepsin L is a kind of cystein proteases which are known to facilitate the invasion and metastasis of tumor cells by degrading the components of basement membrane and extracellular matrix. This study was undertaken to investigate the expression of cathepsin L by Northern blot analysis with radiolabeled cDNA specific for cathepsin L in six normal tissues, two osteosarcoma cell lines, MG-63 and Saos-2, six primary bone tumors and six metastatic bone tumors. In six normal tissues, the highest level of cathepsin L was expressed in liver with the descending order of liver > lung > thymus > ovary > kidney > esophagus. One of the two osteosarcoma cell lines established from the primary sites expressed a high level of cathepsin L mRNA. Out of six primary bone tumors, three (50%) expressed cathepsin L mRNA, while all (100%) of six metastatic bone tumors expressed the mRNA. These results demonstrating the higher frequency of expression of cathepsin L in metastatic bone tumors suggest that cathepsin L may participate in tumor invasion and metastasis.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Neoplasias Óseas
/
ARN Mensajero
/
Cisteína Endopeptidasas
/
Células Tumorales Cultivadas
/
Osteosarcoma
/
Catepsinas
/
Estudios de Casos y Controles
/
Regulación Neoplásica de la Expresión Génica
/
Persona de Mediana Edad
/
Invasividad Neoplásica
Tipo de estudio:
Estudio observacional
Límite:
Adolescente
/
Adulto
/
Femenino
/
Humanos
/
Masculino
Idioma:
Inglés
Revista:
Journal of Korean Medical Science
Año:
1996
Tipo del documento:
Artículo
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