Acute Promyelocytic Leukemia Developed in a Patient with Systemic Lupus Erythematosus / 대한진단검사의학회지
The Korean Journal of Laboratory Medicine
;
: 232-235, 2002.
Artículo
en Coreano
| WPRIM
| ID: wpr-214321
ABSTRACT
A 19-year-old, woman who had been diagnosed as systemic lupus erythematosus (SLE) a year ago, was admitted because of fever, dizziness, and sustained postoperative bleeding after a hemorroidectomy. On admission, a CBC revealed pancytopenia (Hb 6.2 g/dL, WBC 1,200/microL, platelets 11,000/microL) with a shift to themicroLeft, and the FDP and D-dimer were positive. She was treated for sepsis and disseminated intravascular coagulation. Granulocyte colony-stimulating factor (G-CSF) was administrated twice for severe neutropenia. An increase in WBC and immature myeloid cells, mainly hypergranular promyelocytes on the peripheral blood followed and was considered to be the effect of G-CSF. To evaluate the cause of pulmonary infiltrates, bronchoalveolar lavage (BAL) was performed on the 5th day of admission. The BAL fluid revealed many promyelocytes and myelocytes with occasional structures recognized as Auer rods. Acute promyelocytic leukemia (APL) was confirmed on the bone marrow study and chromosome analysis. Unfortunately, the patient died of septic shock on the 9th day of admission. We report here a very rare case of APL diagnosed in a SLE patient, the diagnosis of which was somewhat delayed due to the use of G-CSF and superimposed sepsis.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Pancitopenia
/
Choque Séptico
/
Médula Ósea
/
Leucemia Promielocítica Aguda
/
Factor Estimulante de Colonias de Granulocitos
/
Sepsis
/
Lavado Broncoalveolar
/
Células Mieloides
/
Células Precursoras de Granulocitos
/
Diagnóstico
Tipo de estudio:
Estudio diagnóstico
Límite:
Femenino
/
Humanos
Idioma:
Coreano
Revista:
The Korean Journal of Laboratory Medicine
Año:
2002
Tipo del documento:
Artículo
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