Hyperhomocysteinemia and Cerebrovascular Diseases in Koreans
Journal of the Korean Academy of Family Medicine
;
: 12-20, 2006.
Artículo
en Coreano
| WPRIM
| ID: wpr-214352
ABSTRACT
BACKGROUND:
Hyperhomocysteinemia as a risk factor for cerebrovascular disease is well known. Our aim of this study was to demonstrate positive association between elevated homocysteine levels and cerebrovascular diseases in Koreans.METHODS:
With a case-control design, 186 stroke (infarction 134, hemorrhage 52) patients, diagnosed by brain CT or MRI and 359 control patients were evaluated. We used multiple logistic regression analyses conditioned on the matching variables (sex, age, hypertension, DM, smoking, hyperlipidemia, hyperhomocysteinemia) and calculated odds ratio and 95% CIs.RESULTS:
Multivariated adjusted odds ratios (OR) for cerebrovascular diseases associated with hypertension compared with normal blood pressure were 2.45 (95% CI, 1.16 to 5.15) in prehypertension and 3.33 (95% CI, 1.56 to 7.10) in stage 1 hypertension and 3.77 (95% CI, 1.32 to 10.74) in stage 2 hypertension. OR for cerebrovascular diseases associated with hyperhomocysteinemia compared with or =17 micromol/L.CONCLUSION:
Not only hypertension but also hyperhomocysteinemia was a significant risk factor for cerebrovascular diseases in Koreans.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Humo
/
Presión Sanguínea
/
Encéfalo
/
Imagen por Resonancia Magnética
/
Fumar
/
Estudios de Casos y Controles
/
Modelos Logísticos
/
Oportunidad Relativa
/
Factores de Riesgo
/
Hiperhomocisteinemia
Tipo de estudio:
Estudio de etiología
/
Estudio observacional
/
Estudio pronóstico
/
Factores de riesgo
Límite:
Humanos
Idioma:
Coreano
Revista:
Journal of the Korean Academy of Family Medicine
Año:
2006
Tipo del documento:
Artículo
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