Expression of vascular endothelial growth factor in oral squamous cell carcinoma
Journal of the Korean Association of Oral and Maxillofacial Surgeons
;
: 11-18, 2015.
Artículo
en Inglés
| WPRIM
| ID: wpr-214926
ABSTRACT
OBJECTIVES:
The goal of this study was to determine the correlation of clinicopathological factors and the up-regulation of vascular endothelial growth factor (VEGF) expression in oral squamous cell carcinoma. MATERIALS ANDMETHODS:
Immunohistochemical staining of VEGF and quantitative real-time polymerase chain reaction (RT-PCR) of VEGF mRNA were performed in 20 specimens from 20 patients with oral squamous cell carcinoma and another 20 specimens from 20 patients with carcinoma in situ as a controlled group.RESULTS:
The results were as follows 1) In immunohistochemical study of poorly differentiated and invasive oral squamous cell carcinoma, high-level staining of VEGF was observed. Significant correlation was observed between immunohistochemical VEGF expression and histologic differentiation, tumor size of specimens (Pearson correlation analysis, significance r>0.6, P<0.05). 2) In VEGF quantitative RT-PCR analysis, progressive cancer showed more VEGF expression than carcinoma in situ. Paired-samples analysis determined the difference of VEGF mRNA expression level between cancer tissue and carcinoma in situ tissue, between T1 and T2-4 (Student's t-test, P<0.05).CONCLUSION:
These findings suggest that up-regulation of VEGF may play a role in the angiogenesis and progression of oral squamous cell carcinoma.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
ARN Mensajero
/
Inmunohistoquímica
/
Carcinoma in Situ
/
Carcinoma de Células Escamosas
/
Regulación hacia Arriba
/
Factor A de Crecimiento Endotelial Vascular
/
Reacción en Cadena en Tiempo Real de la Polimerasa
Límite:
Humanos
Idioma:
Inglés
Revista:
Journal of the Korean Association of Oral and Maxillofacial Surgeons
Año:
2015
Tipo del documento:
Artículo
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