The Effect of Adipose-Derived Stem Cell-Cultured Media on Oxazolone Treated Atopic Dermatitis-Like Murine Model
Annals of Dermatology
;
: 181-188, 2012.
Artículo
en Inglés
| WPRIM
| ID: wpr-214974
ABSTRACT
BACKGROUND:
A stem cell is an undifferentiated cell that has the potential for self-renewal and differentiation. Adipose-derived stem cells (ADSCs) have advantages in accessibility and abundance compared to other kinds of stem cells and produce many growth factors and hormones.OBJECTIVE:
We investigated whether ADSC cultured media could be used as a therapy for atopic dermatitis.METHODS:
ADSC cultured media was topically applied twice daily for 5 days to oxazolone-treated atopic dermatitis-like hairless mice.RESULTS:
Topical application of ADSC cultured media improved the epidermal permeability barrier and keratinocyte differentiation, and restored the predominant Th2 phenotype when compared to vehicle. ADSC cultured media-treated epidermis also showed an increase in the expression of antimicrobial peptides cathelin-related antimicrobial peptide, mouse beta-defensein 3.CONCLUSION:
Topical ADSC cultured media could be useful in the treatment of atopic dermatitis.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Péptidos
/
Permeabilidad
/
Fenotipo
/
Células Madre
/
Queratinocitos
/
Oxazolona
/
Péptidos y Proteínas de Señalización Intercelular
/
Dermatitis Atópica
/
Epidermis
/
Catelicidinas
Tipo de estudio:
Estudio pronóstico
Límite:
Animales
Idioma:
Inglés
Revista:
Annals of Dermatology
Año:
2012
Tipo del documento:
Artículo
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