Your browser doesn't support javascript.
loading
Assessment for the Role of Serotonin Receptor Subtype 3 for the Analgesic Action of Morphine at the Spinal Level / 대한통증학회지
The Korean Journal of Pain ; : 113-117, 2005.
Artículo en Coreano | WPRIM | ID: wpr-215230
ABSTRACT

BACKGROUND:

Serotonin 3 receptor is involved in the modulation of nociceptive transmission in the spinal cord. The serotonin 3 receptor antagonist has been used for the management of opioid-induced nausea and vomiting. The aim of this study was to examine whether the analgesic effect of morphine is antagonized by serotonin 3 receptor antagonists at the spinal level.

METHODS:

Rats were implanted with lumbar intrathecal catheters. For nociception, a formalin solution (5%, 50microliter) was injected into the hind paw of male Sprague-Dawley rats. To determine whether the effect of intrathecal morphine was mediated via serotonin 3 receptors, serotonin 3 receptor antagonists were intrathecally administered 10 min prior to the morphine delivery. Following the formalin injection, formalin-induced nociceptive behavior (flinching response) was observed for 60 min.

RESULTS:

Intrathecal morphine produced a dose-dependent suppression of the flinches in both phases during the formalin test. The analgesic action of morphine was not reversed by serotonin 3 receptor antagonists (LY-278, 584, ondansetron), which had little per se effect on the formalin-induced nociception.

CONCLUSIONS:

Spinal serotonin 3 receptors may not be involved in the analgesia of morphine on a nociceptive state evoked by a formalin stimulus.
Asunto(s)

Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Médula Espinal / Vómitos / Dimensión del Dolor / Serotonina / Ratas Sprague-Dawley / Receptores de Serotonina 5-HT3 / Catéteres / Nocicepción / Formaldehído / Analgesia Límite: Animales / Humanos / Masculino Idioma: Coreano Revista: The Korean Journal of Pain Año: 2005 Tipo del documento: Artículo

Similares

MEDLINE

...
LILACS

LIS

Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Médula Espinal / Vómitos / Dimensión del Dolor / Serotonina / Ratas Sprague-Dawley / Receptores de Serotonina 5-HT3 / Catéteres / Nocicepción / Formaldehído / Analgesia Límite: Animales / Humanos / Masculino Idioma: Coreano Revista: The Korean Journal of Pain Año: 2005 Tipo del documento: Artículo