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Immunohistochemical localization of eight phospholipase C isozymes in pancreatic islets of the mouse
Experimental & Molecular Medicine ; : 164-168, 2001.
Artículo en Inglés | WPRIM | ID: wpr-215629
ABSTRACT
The possible involvement of phospholipase C (PLC) in the regulation of insulin secretion is not clearly understood and neither its isozymes expressed nor cellular localization in the pancreatic islets is known. By using specific monoclonal antibodies, we have investigated the expression and localization of eight different PLC isozymes, beta1, beta2, beta3, beta4, gamma1, gamma2, delta1, and delta2, in the pancreatic islets of adult mice. Immunohistochemical analysis carried out on paraffin embedded sections showed a distinct pattern of expression for each of the PLC isozymes. In the central part of the islets containing beta cells, a high level of beta4 and moderate levels of beta3 and gamma1 were expressed, whereas PLC-beta1 and -gamma1 were abundantly expressed in the exocrine pancreas. These results demonstrated the heterogeneity in expression of the phospholipase C isozymes in pancreatic islets. It is conceivable that these isozymes are coupled to different receptors and perform selective tasks in the regulation of insulin secretion for glucose homeostasis.
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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Fosfolipasas de Tipo C / Glucagón / Islotes Pancreáticos / Ratones Noqueados / Insulina / Isoenzimas / Animales / Ratones Endogámicos C57BL / Anticuerpos Monoclonales Límite: Animales Idioma: Inglés Revista: Experimental & Molecular Medicine Año: 2001 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Fosfolipasas de Tipo C / Glucagón / Islotes Pancreáticos / Ratones Noqueados / Insulina / Isoenzimas / Animales / Ratones Endogámicos C57BL / Anticuerpos Monoclonales Límite: Animales Idioma: Inglés Revista: Experimental & Molecular Medicine Año: 2001 Tipo del documento: Artículo