A Rare Case of Transformation of Childhood Myelodysplastic Syndrome to Acute Lymphoblastic Leukemia
Annals of Laboratory Medicine
;
: 130-135, 2013.
Artículo
en Inglés
| WPRIM
| ID: wpr-216010
ABSTRACT
Transformation of MDS into ALL during childhood is extremely rare. We report a rare case of an 8-yr-old girl who presented with refractory cytopenia of childhood (RCC) that transformed into ALL only 3 months after the diagnosis of childhood MDS. Although no cytogenetic abnormalities were observed in conventional karyotype and FISH analysis, we found several deletions on chromosomes 5q, 12q, 13q, and 22q. Partial homozygous deletion of the RB1 gene was observed on microarray analysis, with the bone marrow specimen diagnosed as ALL. This is the first case report of transformation of ALL from childhood MDS in Korea. We also compared the clinical, cytological, and cytogenetic features of 4 previously reported childhood MDS cases that transformed into ALL.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Síndromes Mielodisplásicos
/
Células de la Médula Ósea
/
Transformación Celular Neoplásica
/
Proteína de Retinoblastoma
/
Aberraciones Cromosómicas
/
Hibridación Fluorescente in Situ
/
Eliminación de Gen
/
Leucemia-Linfoma Linfoblástico de Células Precursoras
/
Cariotipificación
Límite:
Niño
/
Femenino
/
Humanos
Idioma:
Inglés
Revista:
Annals of Laboratory Medicine
Año:
2013
Tipo del documento:
Artículo
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