Potential Serum Markers for Monitoring the Progression of Hepatitis B Virus-Associated Chronic Hepatic Lesions to Liver Cirrhosis
Gut and Liver
; : 665-671, 2015.
Article
en En
| WPRIM
| ID: wpr-216102
Biblioteca responsable:
WPRO
ABSTRACT
BACKGROUND/AIMS: To screen for serum protein/peptide biomarkers of hepatitis B virus (HBV)-associated chronic hepatic lesions in an attempt to profile the progression of HBV-associated chronic hepatic lesions using surface-enhanced laser desorption/ionization time-of-flight mass spectrometry (SELDI-TOF MS) techniques. METHODS: Using SELDI-TOF MS, serum protein/peptide profiles on the CM10 ProteinChip arrays were obtained from a training group including 26 HBV-associated hepatocellular carcinoma patients with liver cirrhosis (LC), 30 HBV-associated LC patients, 85 patients at different stages of liver fibrosis, and 30 asymptomatic HBV carriers. The most valuable SELDI peak for predicting the progression to LC in HBV-infected patients was identified. RESULTS: A SELDI peak of M/Z 5805 with value for predicting LC in HBV-infected patients was found and was identified as a peptide of the C-terminal fraction of the fibrinogen alpha-chain precursor, isoform 1. CONCLUSIONS: The peptide of the C-terminal fraction of the fibrinogen alpha-chain precursor, isoform 1 with M/Z 5805, may be a serological biomarker for progression to LC in HBV-infected patients.
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Texto completo:
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Índice:
WPRIM
Asunto principal:
Biomarcadores
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Virus de la Hepatitis B
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Carcinoma Hepatocelular
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Progresión de la Enfermedad
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Espectrometría de Masa por Láser de Matriz Asistida de Ionización Desorción
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Hepatitis B Crónica
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Análisis por Matrices de Proteínas
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Cirrosis Hepática
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Neoplasias Hepáticas
Tipo de estudio:
Prognostic_studies
Límite:
Adult
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Aged
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Female
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Humans
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Male
Idioma:
En
Revista:
Gut and Liver
Año:
2015
Tipo del documento:
Article