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Potential Serum Markers for Monitoring the Progression of Hepatitis B Virus-Associated Chronic Hepatic Lesions to Liver Cirrhosis
Gut and Liver ; : 665-671, 2015.
Article en En | WPRIM | ID: wpr-216102
Biblioteca responsable: WPRO
ABSTRACT
BACKGROUND/AIMS: To screen for serum protein/peptide biomarkers of hepatitis B virus (HBV)-associated chronic hepatic lesions in an attempt to profile the progression of HBV-associated chronic hepatic lesions using surface-enhanced laser desorption/ionization time-of-flight mass spectrometry (SELDI-TOF MS) techniques. METHODS: Using SELDI-TOF MS, serum protein/peptide profiles on the CM10 ProteinChip arrays were obtained from a training group including 26 HBV-associated hepatocellular carcinoma patients with liver cirrhosis (LC), 30 HBV-associated LC patients, 85 patients at different stages of liver fibrosis, and 30 asymptomatic HBV carriers. The most valuable SELDI peak for predicting the progression to LC in HBV-infected patients was identified. RESULTS: A SELDI peak of M/Z 5805 with value for predicting LC in HBV-infected patients was found and was identified as a peptide of the C-terminal fraction of the fibrinogen alpha-chain precursor, isoform 1. CONCLUSIONS: The peptide of the C-terminal fraction of the fibrinogen alpha-chain precursor, isoform 1 with M/Z 5805, may be a serological biomarker for progression to LC in HBV-infected patients.
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Texto completo: 1 Índice: WPRIM Asunto principal: Biomarcadores / Virus de la Hepatitis B / Carcinoma Hepatocelular / Progresión de la Enfermedad / Espectrometría de Masa por Láser de Matriz Asistida de Ionización Desorción / Hepatitis B Crónica / Análisis por Matrices de Proteínas / Cirrosis Hepática / Neoplasias Hepáticas Tipo de estudio: Prognostic_studies Límite: Adult / Aged / Female / Humans / Male Idioma: En Revista: Gut and Liver Año: 2015 Tipo del documento: Article
Texto completo: 1 Índice: WPRIM Asunto principal: Biomarcadores / Virus de la Hepatitis B / Carcinoma Hepatocelular / Progresión de la Enfermedad / Espectrometría de Masa por Láser de Matriz Asistida de Ionización Desorción / Hepatitis B Crónica / Análisis por Matrices de Proteínas / Cirrosis Hepática / Neoplasias Hepáticas Tipo de estudio: Prognostic_studies Límite: Adult / Aged / Female / Humans / Male Idioma: En Revista: Gut and Liver Año: 2015 Tipo del documento: Article