Inhibitory Effect of a Sesquiterpene from Artemisia iwayomogi on Expression of Inducible Nitric Oxide Synthase by Suppression of I-κBα Degradation in LPS-stimulated RAW 264.7 Cells
Natural Product Sciences
;
: 92-96, 2017.
Artículo
en Inglés
| WPRIM
| ID: wpr-216623
ABSTRACT
A sesquiterpene was purified from Artemisia iwayomogi methanolic extract during the course of searching anti-inflammatory principle from medicinal plants. A sesquiterpene identified as armefolin inhibited the production of nitric oxide (NO) and attenuated inducible nitric oxide synthase (iNOS) protein level in lipopolysaccharide (LPS)-activated RAW 264.7 cells. Armefolin also down-regulated mRNA expressions of iNOS and pro-inflammatory cytokines, interleukin-1β and interleukin-6 in LPS-activated macrophages. Moreover, armefolin suppressed the degradation of inhibitory-κBα (I-κBα) in LPS-activated macrophages. These data suggest that armefolin from A. iwayomogi can suppress the LPS-induced production of NO and the expression of iNOS gene through inhibiting the degradation of I-κBα. Taken together, armefolin from A. iwayomogi might be a candidate as promising anti-inflammatory agent.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Plantas Medicinales
/
ARN Mensajero
/
Citocinas
/
Interleucina-6
/
Artemisia
/
Metanol
/
Óxido Nítrico Sintasa de Tipo II
/
Macrófagos
/
Óxido Nítrico
Tipo de estudio:
Estudio pronóstico
Idioma:
Inglés
Revista:
Natural Product Sciences
Año:
2017
Tipo del documento:
Artículo
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