A Case of Zonisamide-Induced Stevens-Johnson Syndrome / 대한내과학회지

ABSTRACT

Stevens-Johnson syndrome (SJS) is a rare but severe disorder typically caused by medications and characterized by mucocutaneous eruptions. Zonisamide is an antiepileptic drug that is structurally different from other drugs of the same class. It is considered safe for patient use, and few cases describing severe cutaneous adverse reactions from zonisamide have been reported. We herein report a case of zonisamide-induced SJS in a 36-year-old woman. The patient presented with a widespread erythematous maculopapular rash after taking zonisamide. The symptoms of SJS improved after zonisamide was discontinued and systemic steroids and intravenous immunoglobulins were administered. This is the first case of zonisamide-induced SJS in Korea. Although this drug is generally considered safe, we suggest that clinicians be aware of potential adverse reactions, including SJS.