A Novel MUT Gene Mutation Detected in a Female Infant with Methylmalonic Acidemia
Neonatal Medicine
; : 51-54, 2015.
Article
en Ko
| WPRIM
| ID: wpr-217679
Biblioteca responsable:
WPRO
ABSTRACT
Methylmalonic acidemia (MMA) is an autosomal recessive metabolic disease. MMA results from a deficiency of L-methylmalonyl-CoA mutase (encoded by MUT), its cofactor 5-deoxyadenosylcobalamin (MMAA, MMAB, and MMADHC), or a deficiency of methylmalonyl CoA-epimerase (MCEE). We report the case of a 5-day-old infant with MMA in which a missense and a novel nonsense mutation in MUT were present. Direct sequencing analysis of MUT revealed a heterozygous c.1106G>A (p.Arg369His) mutation in exon 6 and a heterozygous c.362_368dupAGTTCTA (p.Tyr123*) mutation in exon 2; the latter results in a premature stop codon.
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Texto completo:
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Índice:
WPRIM
Asunto principal:
Exones
/
Codón sin Sentido
/
Enfermedades Metabólicas
Límite:
Female
/
Humans
/
Infant
Idioma:
Ko
Revista:
Neonatal Medicine
Año:
2015
Tipo del documento:
Article