The Change of Tumor Interstitial Fluid Pressure by Radiation Therapy in Patients with Metastatic Lymph Node in Head and Neck Area / 대한방사선종양학회지

ABSTRACT

PURPOSE: To determine if the tumor intersitial fluid pressure (TIFP) and/or its change in patients with metastatic lymph node in head and neck area can predict radiotherapy outcome. MATERIALS AND METHODS: In 26 biopsy proven metastatic lymph node patients in head and neck area with accessible by direct inspection and palpation, and of sufficient thickness (>1 cm) to permit accurate needle placement, we measured TIFP at cervical lymph node before and during radiotherapy. Tumor size was measured clinically and radiologically. RESULTS: The mean preradiotherapy TIFP was 24.7 mmHg. Preradiotherapy TIFP had marginally significant relationship with tumor size ( p=0.06). Preradiotherapy TIFP significantly decreased when tumor size decreased ( p=0.009). Preradiotherapy TIFP was not different between complete response group and group with partial or less respone ( p=0.75). Radiotherapy outcome was not different between group with above and group with below than average TIFP ( p=0.229). TIFP decreased 36 mmHg in complete response group and 29.7 mmHg in group with partial or less respone. CONCLUSION: The mean TIFP was elevated with 24.7 mmHg. Preradiotherapy TIFP had marginally significant relationship with tumor size ( p=0.06). TIFP decreased 36 mmHg in complete response group and 29.7 mmHg in group with partial or less respone but there was no statistically significant relationship in two groups.