In Vivo Experiment of Tissue-Engineered Artificial Vessel / 대한흉부외과학회지
The Korean Journal of Thoracic and Cardiovascular Surgery
;
: 220-227, 2004.
Artículo
en Coreano
| WPRIM
| ID: wpr-218685
ABSTRACT
BACKGROUND:
The number of patients with coronary artery disease and peripheral vascular disease are increasing, and the need of small diameter vessel is also increasing. We developed small diameter artificial vessel and experimented in vivo. MATERIAL ANDMETHOD:
We got allogenic valve from mongrel dogs, and removed all cells from the allogenic valve. Then, we seeded autologous bone marrow cells onto the decellularized scaffold. After implantation of artificial vessel into the canine carotid artery, we performed angiography regularly. In case of vessel occlusion or at 8 weeks after operation, we euthanized dogs, and retrieved the implanted artificial vessels.RESULT:
Control vessels were all occluded except one (which developed aneurysmal dilatation). But autologous cell seeded vascular graft were patent by 4 weeks in one, by 6 in one and by 8 weeks in two. Histologic examination of patent vessel revealed similar structure to native artery.CONCLUSION:
Tissue-engineered vascular graft manufactured with decellularized allogenic matrix and autologous bone marrow cells showed that tissue engineered graft had similar structure to native artery.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Arterias
/
Enfermedad de la Arteria Coronaria
/
Prótesis Vascular
/
Células de la Médula Ósea
/
Angiografía
/
Arterias Carótidas
/
Enfermedades Vasculares Periféricas
/
Trasplantes
/
Ingeniería de Tejidos
/
Aneurisma
Límite:
Animales
/
Humanos
Idioma:
Coreano
Revista:
The Korean Journal of Thoracic and Cardiovascular Surgery
Año:
2004
Tipo del documento:
Artículo
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