A Case of Classic Kaposi's Sarcoma Showing Good Response to Radiotherapy / 대한피부과학회지

ABSTRACT

Kaposi's sarcoma is a neoplasm of multifocal origin which manifests primarily as vascular nodules in the skin and other organs. We report a case of classic Kaposi's sarcoma in a 79-year-old man who had asymptomatic dark-brown macules, papules and nodules on his Rt. lower extremities. The biopsy specimen showed typical histopathologic features of Kaposi's sarcoma including dilated, bizarre-shaped vessels, endothelial cell proliferation, and spindle cell formation with vascular slits throughout the dermis. Many of the spindle-shaped cells associated with the proliferating vessels in Kaposi's sarcoma lesion expressed factor VIII-related antigen. Initially he was treated with 4,000 rads of radiation(200 rad per day for 20 successive days), and after two months 2,500 rads of radiation(500 rad per day for 5 successive days). Three months after radiotherapy, skin lesions were healed leaving hyperpigmentation.