Reference values of clinical pathology parameters in cynomolgus monkeys (Macaca fascicularis) used in preclinical studies / 한국실험동물학회지
Laboratory Animal Research
;
: 79-86, 2016.
Artículo
en Inglés
| WPRIM
| ID: wpr-221209
ABSTRACT
Nonhuman primates are increasingly used in biomedical research since they are highly homologous to humans compared to other rodent animals. However, there is limited reliable reference data of the clinical pathology parameters in cynomolgus monkeys, and in particular, only some coagulation and urinalysis parameters have been reported. Here, we reported the reference data of clinical chemical, hematological, blood coagulation, and urinalysis parameters in cynomolgus monkeys. The role of sex differences was analyzed and several parameters (including hematocrit, hemoglobin, red blood cell, blood urea nitrogen, total bilirubin, alkaline phosphatase, creatinine kinase, gamma-glutamyl tranferase, and lactate dehydrogenase) significantly differed between male and female subjects. In addition, compared to previous study results, lactate dehydrogenase, creatinine kinase, and aspartate aminotransferase showed significant variation. Interstudy differences could be affected by several factors, including age, sex, geographic origin, presence/absence of anesthetics, fasting state, and the analytical methods used. Therefore, it is important to deliberate with the overall reference indices. In conclusion, the current study provides a comprehensive and updated reference data of the clinical pathology parameters in cynomolgus monkeys and provides improved assessment criteria for evaluating preclinical studies or biomedical research.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Patología Clínica
/
Fosfotransferasas
/
Primates
/
Aspartato Aminotransferasas
/
Valores de Referencia
/
Roedores
/
Bilirrubina
/
Coagulación Sanguínea
/
Nitrógeno de la Urea Sanguínea
/
Química Clínica
Límite:
Animales
/
Femenino
/
Humanos
/
Masculino
Idioma:
Inglés
Revista:
Laboratory Animal Research
Año:
2016
Tipo del documento:
Artículo
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