Midtrimester maternal plasma concentrations of angiopoietin 1, angiopoietin 2, and placental growth factor in pregnant women who subsequently develop preeclampsia
Obstetrics & Gynecology Science
;
: 10-16, 2015.
Artículo
en Inglés
| WPRIM
| ID: wpr-221369
ABSTRACT
OBJECTIVE:
The aim of this study was to compare midtrimester maternal plasma concentrations of angiopoietin 1, angiopoietin 2, and placental growth factor between pregnant women who subsequently developed preeclampsia and those who did not.METHODS:
Midtrimester maternal plasma was collected and stored at -70degrees C when genetic amniocentesis was performed. Cases included 37 samples of individual who subsequently developed preeclampsia, and matched controls were from individuals who did not develop preeclampsia. Angiopoietin 1, angiopoietin 2, and placental growth factor concentrations were measured by the enzyme-linked immunosorbent assay method and were compared using the Mann-Whitney U-test. A P-value <0.05 was considered significant.RESULTS:
In pregnant women who subsequently developed preeclampsia, midtrimester maternal plasma concentrations of angiopoietin 1 and angiopoietin 2 were significantly higher and placental growth factor concentrations were significantly lower than in women who did not develop preeclampsia (angiopoietin 1 10.6 [3.1-19.7] vs. 7.8 [0.9-24.4] ng/mL, P=0.031; angiopoietin 2 31.0 [4.7-81.2] vs. 18.4 [4.2-49.7] ng/mL, P<0.001; placental growth factor 87.1 [14.2-774.3] vs. 148.8 [57.2-425.6] pg/mL, P<0.001). Within the case group who subsequently developed preeclampsia, the placental growth factor was significantly lower in those who had fetal growth restrictions than in those who did not (placental growth factor 72.5 [14.2-774.3] vs. 140.9 [44.2-257.5] pg/mL, P=0.003).CONCLUSION:
Midtrimester maternal plasma concentrations of angiopoietin 1, angiopoietin 2, and placental growth factor may be associated with the subsequent development of preeclampsia.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Plasma
/
Preeclampsia
/
Segundo Trimestre del Embarazo
/
Ensayo de Inmunoadsorción Enzimática
/
Mujeres Embarazadas
/
Angiopoyetina 1
/
Angiopoyetina 2
/
Desarrollo Fetal
/
Amniocentesis
Límite:
Femenino
/
Humanos
/
Embarazo
Idioma:
Inglés
Revista:
Obstetrics & Gynecology Science
Año:
2015
Tipo del documento:
Artículo
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