Autophagy Activity in Pulmonary Metastatic Tumor Tissues from Colorectal Cancer: A Pilot Study
Yonsei Medical Journal
;
: 1484-1488, 2014.
Artículo
en Inglés
| WPRIM
| ID: wpr-221615
ABSTRACT
PURPOSE:
Autophagy has been reported to be involved in treatment failure in tumor. We aimed to evaluate autophagy activity in tumor tissue and compare them between the recurrence and non-recurrence groups. MATERIALS ANDMETHODS:
We analyzed expressions of autophagy-related proteins in tumor tissues which were obtained from pulmonary metastases of colorectal cancer patients by Western blot. We also analyzed autophagosomes by transmission electron microscopy.RESULTS:
Tumor tissues from recurrence group showed increased levels of LC3B-II, decreased levels of p62/SQSTM1, and also a marked accumulation of autophagosomes compared with tissues from non-recurrence group.CONCLUSION:
The present study suggests that autophagy may be associated with treatment failure of metastatic colorectal cancer.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Autofagia
/
Neoplasias Colorrectales
/
Proteínas
/
Biomarcadores de Tumor
/
Proyectos Piloto
/
Western Blotting
/
Estudios Retrospectivos
/
Insuficiencia del Tratamiento
/
Proteínas Adaptadoras Transductoras de Señales
/
Microscopía Electrónica de Transmisión
Tipo de estudio:
Estudio observacional
Límite:
Anciano
/
Femenino
/
Humanos
/
Masculino
Idioma:
Inglés
Revista:
Yonsei Medical Journal
Año:
2014
Tipo del documento:
Artículo
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