Eosinophils and Type 2 Cytokine Signaling in Macrophages Support the Biogenesis of Cold-induced Beige Fat
Journal of Bacteriology and Virology
; : 44-46, 2016.
Article
en En
| WPRIM
| ID: wpr-221988
Biblioteca responsable:
WPRO
ABSTRACT
Brown adipose generates heat via oxidation of fatty acids by a mitochondrial uncoupling protein 1 (UCP1)-dependent process. In addition, a subpopulation of cells within subcutaneous white adipose tissue, known as beige adipocytes, also plays a role in thermogenesis. The biogenesis of beige adipocytes is induced by thermogenic signals, such as chronic cold exposure. Recently, it has been reported that eosinophils, type 2 cytokines of IL-4/13, and alternatively activated macrophages control the thermogenic cycle of beige adipocytes. Alternatively, activated macrophages induce UCP1+ beige adipocytes through secretion of catecholamines. These results define the role of type 2 immune responses in the regulation of energy homeostasis.
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Texto completo:
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Índice:
WPRIM
Asunto principal:
Biogénesis de Organelos
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Tejido Adiposo Pardo
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Catecolaminas
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Citocinas
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Adipocitos
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Termogénesis
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Eosinófilos
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Tejido Adiposo Blanco
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Ácidos Grasos
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Calor
Idioma:
En
Revista:
Journal of Bacteriology and Virology
Año:
2016
Tipo del documento:
Article