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Eosinophils and Type 2 Cytokine Signaling in Macrophages Support the Biogenesis of Cold-induced Beige Fat
Journal of Bacteriology and Virology ; : 44-46, 2016.
Artículo en Inglés | WPRIM | ID: wpr-221988
ABSTRACT
Brown adipose generates heat via oxidation of fatty acids by a mitochondrial uncoupling protein 1 (UCP1)-dependent process. In addition, a subpopulation of cells within subcutaneous white adipose tissue, known as beige adipocytes, also plays a role in thermogenesis. The biogenesis of beige adipocytes is induced by thermogenic signals, such as chronic cold exposure. Recently, it has been reported that eosinophils, type 2 cytokines of IL-4/13, and alternatively activated macrophages control the thermogenic cycle of beige adipocytes. Alternatively, activated macrophages induce UCP1+ beige adipocytes through secretion of catecholamines. These results define the role of type 2 immune responses in the regulation of energy homeostasis.
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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Biogénesis de Organelos / Tejido Adiposo Pardo / Catecolaminas / Citocinas / Adipocitos / Termogénesis / Eosinófilos / Tejido Adiposo Blanco / Ácidos Grasos / Calor Idioma: Inglés Revista: Journal of Bacteriology and Virology Año: 2016 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Biogénesis de Organelos / Tejido Adiposo Pardo / Catecolaminas / Citocinas / Adipocitos / Termogénesis / Eosinófilos / Tejido Adiposo Blanco / Ácidos Grasos / Calor Idioma: Inglés Revista: Journal of Bacteriology and Virology Año: 2016 Tipo del documento: Artículo