Immunomodulatory Effects of ZYM-201 on LPS-stimulated B Cells
Immune Network
;
: 260-264, 2014.
Artículo
en Inglés
| WPRIM
| ID: wpr-222050
ABSTRACT
ZYM-201 is a methyl ester of triterpenoid glycoside from Sanguisorba officinalis which has been used for treatment of inflammatory and metabolic diseases. In this study, immunomodulatory effects of ZYM-201 on B cells were examined in vitro and in vivo. When splenocytes were activated with lipopolysaccharide (LPS), the major population which had shown an increase in cell numbers was B cells. However, when the B cells were treated with ZYM-201 after LPS activation, their cell numbers and the expression of major costimulatory molecules, CD80 and CD86, were decreased. Furthermore, the effect of LPS, which induces activation of NF-kappaB, was abolished by ZYM-201 LPS-stimulated B cells showed decrease of phosphorylation after treatment of ZYM-201. The same results were shown in vivo experiments. These results suggest that ZYM-201 may play a role in the modulation of inflammatory responses through inhibiting NF-kappaB activation and downregulating the expression of costimulatory molecules on B cells.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Fosforilación
/
Linfocitos B
/
Recuento de Células
/
FN-kappa B
/
Sanguisorba
/
Inflamación
/
Enfermedades Metabólicas
Idioma:
Inglés
Revista:
Immune Network
Año:
2014
Tipo del documento:
Artículo
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