Case Report of Menopausal Woman Diagnosed with Endometrial Cancer after Colon Cancer with Germline Mutation in MSH6 in Korea
Journal of Menopausal Medicine
;
: 69-73, 2017.
Artículo
en Inglés
| WPRIM
| ID: wpr-222375
ABSTRACT
We present a case of an endometrial cancer patient with germline mutation in MutS homolog 6 (MSH6), associated with Lynch syndrome. A 60-year-old Korean woman had a personal history of colon cancer 23 years ago. She also had a family history of endometrial cancer and colon cancer of her sisters and brothers. Immunohistochemistry was negative for MutL homolog 1 (MLH1) and positive for MutS homolog 2 (MSH2). Based on these findings, she underwent genetic counseling and testing that revealed a frameshift germline mutation at MSH6 (c. 3261dupC).
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Inmunohistoquímica
/
Neoplasias Colorrectales Hereditarias sin Poliposis
/
Neoplasias Endometriales
/
Colon
/
Neoplasias del Colon
/
Mutación de Línea Germinal
/
Hermanos
/
Asesoramiento Genético
/
Corea (Geográfico)
Tipo de estudio:
Estudio diagnóstico
Límite:
Femenino
/
Humanos
País/Región como asunto:
Asia
Idioma:
Inglés
Revista:
Journal of Menopausal Medicine
Año:
2017
Tipo del documento:
Artículo
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